2026-10-23 · ArXiv
arXiv:2610.08944v2 Announce Type: replace-cross
Abstract: Scanner variation changes how pathology foundation models represent the same tissue. We introduce SlideRuler, which uses other regions within a slide as internal controls to predict a query region's scanner-induced shift. A transfer map learned from paired rescans enables calibration from a single scan at inference while keeping the foundation model fixed. Across two encoders and five SCORPION scanners, learned transfer reduces mean target-to-source embedding distance by 16.3-38.5% relative to raw embeddings. Replacing controls with unrelated same-scanner regions reveals a positive same-slide contribution in all four evaluation settings, including scanner holdout. A source-anchored variant reduces source-feature displacement by 47.7-83.6% relative to learned transfer while retaining most of its alignment gain. By drawing calibration information from the slide itself, SlideRuler offers a path toward more consistent use of frozen pathology models across imaging systems.
原文链接：https://arxiv.org/abs/2610.08944
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